Anti-GJB2 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P29033\|A2VE67\|P46691
Gene Id	2706
Gene Symbols	GJB2
Protein Name / Synonyms	Gap junction beta-2 protein, Connexin-26, Cx26, GJB2
Clonality	Polyclonal
Clone	RB1228
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Immunohistochemical staining of human cochlear cells demonstrated high levels of GJB2 expression. Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Other Information

NCBI Accession #

NP_003995.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Calculated Molecular Weight (Da)

26215

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of hGJB2-C218.Connexin (Cat. #102-22123) in mouse brain tissue lysates (35ug/lane). GJB2 (arrow) was detected using the purified Pab.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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