3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-Glycoprotein 2 / GP2 / ZAP75 Antibody, Sodium Azide Free
Catalog #: 188-11102-SAF
Mouse anti-Human Glycoprotein 2 Antibody / GP2 / ZAP75 [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | P55259 |
| Gene Id | 2813 |
| Gene Symbols | GP2 |
| Protein Name / Synonyms | Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75) |
| Immunogen | A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody. |
| Isotype | IgG2b, Lambda |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | FACS: 0.5-1ug/10e6 cells in 0.1ml Immunofluorescence: 0.5-1ug/ml IHC (FFPE): 1-2ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cytoplasmic, membranous, secreted |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Storage
Store the GP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.