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Anti-GRPR (Center) Antibody
Catalog #: 102-27803
Rabbit Anti-GRPR (Center) Antibody, 400 µl
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P52500|P30550|P21729 |
| Gene Id | 2925 |
| Gene Symbols | GRPR |
| Protein Name / Synonyms | Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR |
| Clonality | Polyclonal |
| Clone | RB24634 |
| Isotype | IgG |
| Recommended Applications | IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Other Information
NCBI Accession #
NP_005305.1
Antigen Type
Synthetic Peptide
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Calculated Molecular Weight (Da)
43199
Antigen Source
Human
Images
IHC-P (1:50~100)
GRPR Antibody (Center) (Cat. #102-27803) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GRPR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.