Anti-HAX1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O00165
Gene Id	10456
Gene Symbols	HAX1
Protein Name / Synonyms	HAX1 (C-term)
Clonality	Polyclonal
Preparation	This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the C-terminal region of human HAX1.
Concentration (lot specific)	0.250 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

Specificity

Other Names

HAX1; HS1BP1; HCLS1-associated protein X-1; HS1-associating protein X-1; HS1-binding protein 1

NCBI Accession #

NP_001018238.1;NP_006109.2

Other Accession #

NP_001018238.1; NP_006109.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

31621

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	HAX1 Antibody (C-term) (Cat# 102-11499) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the HAX1 antibody detected the HAX1 protein (arrow).
	HAX1 Antibody (C-term) (Cat# 102-11499)immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HAX1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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