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Anti-HLA-DP + HLA-DQ + HLA-DR Antibody (MHC II), Sodium Azide Free
Catalog #: 188-11139-SAF
Mouse anti-Human HLA-DP + HLA-DQ + HLA-DR Antibody (MHC II) [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | P04440,P01909,P01920,P01903 |
| Gene Id | 3117|3119|3122|3115 |
| Gene Symbols | HLA-DQA1,HLA-DQB1,HLA-DRA,HLA-DPB1,HLA-DP1B,HLA-DRA1,HLA-DQB |
| Protein Name / Synonyms | HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1), HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1), HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen DQB1), HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA) |
| Immunogen | Human tonsil cells were used as the immunogen for the HLA-DP/DQ/DR antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | Western Blotting: 1-2ug/ml Immunofluorescence: 0.5-1ug/ml Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cytoplasmic and cell surface |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
This mAb reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some auto-immune diseases are associated with certain class II alleles.
Storage
Store the HLA-DP/DQ/DR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.