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Anti-HP1-gamma Antibody
Catalog #: 102-26644
Mouse Anti-HP1-gamma Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Mouse |
| Accession Number | Q13185 |
| Gene Id | 11335 |
| Gene Symbols | CBX3 |
| Protein Name / Synonyms | CBX 3;CBX3 ;CBX3_HUMAN;Chromobox homolog 3 (HP1 gamma homolog, Drosophila);Chromobox homolog 3;Chromobox protein homolog 3 ;GAM |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting, ICC, IP, IHC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:1000)
Western blot detection of HP1-gamma in Hela,3T3,C6,COS7 and CHO-K1 cell lysates using HP1-gamma mouse mAb (1:1000 diluted).Predicted band size:22KDa.Observed band size:22KDa.
ICC (1:200)
Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-HP1-gamma mouse mAb (dilution 1:200).
IP (1:500)
Immunoprecipitation analysis of Hela cell lysates using HP1-gamma mouse mAb.
IHC (1:100)
Immunohistochemical analysis of paraffin-embedded Prostate Cancer using HP1-gamma mouse mAb (1/200 dilution).Antigen retrieval was performed by pressure cooking in citrate buffer (pH 6.0).
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.