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Anti-HTR2C (Center) Antibody
Catalog #: 102-12207
Rabbit Anti-Human HTR2C (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P28335 |
| Gene Id | 3358 |
| Gene Symbols | HTR2C |
| Protein Name / Synonyms | HTR2C (Center) |
| Clonality | Polyclonal |
| Preparation | This HTR2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human HTR2C. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Neuroscience |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
Specificity
Other Names
HTR2C; HTR1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; Serotonin receptor 2C
NCBI Accession #
NP_000859.1;NP_001243689.1;NP_001243690.1
Other Accession #
NP_000859.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
51821
Recommended Dilutions
WB: 1:1000
 | HTR2C Antibody (Center) (Cat# 102-12207) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the HTR2C antibody detected the HTR2C protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.