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Anti-Human FoxP3 Antibody, Biotinylated
Catalog #: 136-01050
Human FoxP3 Biotinylated Antibody [clone: PCRP-FOXP3-1B2], monoclonal Mouse IgG2a, kappa. Validated for flow cytometry.
Product Description
Specifications
| Size | 100 µg, 500 µg |
| Estimated Lead Time | 3-5 business days |
| Species | Human |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Clone | PCRP-FOXP3-1B2 |
| Conjugation | Biotin |
| Preparation | The antibody was purified by affinity chromatography, and conjugated with biotin. |
| Isotype | IgG2a Kappa |
| Format | Liquid |
| Concentration (lot specific) | 0.5 mg/ml |
| Buffers | PBS, pH 7.2-7.4, 0.2% BSA, 0.1% sodium azide |
| Recommended Applications | Flow Cytometry |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | 4°C |
Description
Product Features
- Serum-free media used for cell culture of hybridomas to minimize bovine antibody contamination
- Gentle elution at pH 4.0 to minimize antibody degradation
- Protein A, G & L affinity purification
- High purity
Description
FOXP3, a 50-55 kD transcription factor, also known as Forkhead box protein P3, is a member of the FOX protein family. FOXP3 functions as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells negatively regulate the immune response. FoxP3 is the main gene and specific marker of regulatory T cells. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.