Anti-HYAL2 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q12891
Gene Id	8692
Gene Symbols	HYAL2
Protein Name / Synonyms	HYAL2 (C-term)
Clonality	Polyclonal
Preparation	This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of human HYAL2.
Concentration (lot specific)	0.460 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Research Area	Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

Specificity

Other Names

HYAL2; LUCA2; Hyaluronidase-2; Hyaluronoglucosaminidase-2; Lung carcinoma protein 2

NCBI Accession #

NP_003764.3;NP_149348.2

Other Accession #

NP_003764.3

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

53860

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100; FC: 1:10-50

	HYAL2 Antibody (C-term) (Cat# 102-10776) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HYAL2 antibody detected the HYAL2 protein (arrow).
	HYAL2 Antibody (C-term) (Cat# 102-10776) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HYAL2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	HYAL2 Antibody (C-term) (Cat# 102-10776) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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