Anti-IGF-1 Antibody

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein in humans encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by under-nutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio.

The Mouse anti-human IGF-1 binds to the target derived from human recombinant protein at various concentrations. Cross reactivity with mouse and rat was not tested

Store at 4^°C if intended for use within one month, otherwise, store at -20^°C to -80^°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20^°C to -80^°C. After reconstitution, it can be aliquoted and stored frozen at -20^°C to -80^°C in a manual defrost freezer for 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4^°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.