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Anti-IL12_2 (C-term) Antibody
Catalog #: 102-10757
Rabbit Anti-Human IL12_2 (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q99665 |
| Gene Id | 3595 |
| Gene Symbols | IL12RB2 |
| Protein Name / Synonyms | IL12_2 (C-term) |
| Clonality | Polyclonal |
| Preparation | This IL12_2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-783 amino acids from the C-terminal region of human IL12_2. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | FC, Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Specificity
Other Names
IL12RB2; Interleukin-12 receptor subunit beta-2
NCBI Accession #
NP_001245143.1;NP_001245144.1;NP_001245145.1;NP_001550.1
Other Accession #
NP_001550.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
97135
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; FC: 1:10-50
 | IL12RB2 Antibody (C-term) (Cat# 102-10757) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the IL12RB2 antibody detected the IL12Cat#2 protein (arrow). |
 | IL12RB2 Antibody (C-term) (Cat# 102-10757) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsils tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IL12RB2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | IL12RB2 Antibody (C-term) (Cat# 102-10757) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.