Anti-INPP5D (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q92835
Gene Id	3635
Gene Symbols	INPP5D
Protein Name / Synonyms	INPP5D (Center)
Clonality	Polyclonal
Preparation	This INPP5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-796 amino acids from the Central region of human INPP5D.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

INPP5D; SHIP; SHIP1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SH2 domain-containing inositol 5'-phosphatase 1; p150Ship

NCBI Accession #

NP_001017915.1;NP_005532.2

Other Accession #

P97573; Q9ES52

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

133292

Recommended Dilutions

WB: 1:1000

Western blot analysis of INPP5D (arrow) using rabbit polyclonal INPP5D Antibody (Center) (Cat# 102-15179). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2) (Origene Technologies).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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