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Anti-Integrin beta 3 / ITGB3 / CD61 Antibody, Sodium Azide Free
Catalog #: 188-11029-SAF
Mouse anti-Human Integrin beta 3 Antibody / ITGB3 / CD61 [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | P05106 |
| Gene Id | 3690 |
| Gene Symbols | ITGB3,GP3A |
| Protein Name / Synonyms | Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) |
| Immunogen | Phytohemagglutinin (PHA)-stimulated peripheral blood cells were used as the immunogen for the CD61 antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | Flow Cytometry: 0.5-1ug/million cells in 0.1ml Immunofluorescence: 0.5-1ug/ml IHC (FFPE): 1-2ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cell surface, cytoplasmic |
| Research Area | Angiogenesis, Cell Adhesion |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Reacts with human CD61, also called Integrin beta 3 (GPIIIa, vitronectin receptor beta chain). It associates with the alphaV-chain (CD51) to form vitronectin receptor, or with the alphaIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Storage
Store the CD61 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.