Anti-Integrin beta 3 (N-terminus) Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Mouse
Accession Number	P05106
Gene Id	3690
Gene Symbols	ITGB3
Protein Name / Synonyms	BDPLT2;CD 61;CD61;CD61 antigen;GP3A;GPIIIa;GT;HPA 1;HPA 4;Integrin beta 3 (platelet glycoprotein IIIa antigen CD61);Integrin beta chain beta 3;Integrin beta-3;ITB3_HUM
Clonality	Monoclonal
Recommended Applications	Western Blotting
Research Area	Angiogenesis, Cell Adhesion
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Other Information

Antigen Type

Recombinant Protein

Images

WB (1:1000)

Western blot detection of Integrin beta 3(N-terminus) in 15ug and 25ug Leukocyte whole cell lysate using Integrin beta 3(N-terminus) mouse mAb (1:1000 diluted).Predicted band size:110KDa.Observed band size:110KDa.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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