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Anti-IREB2 (Center) Antibody
Catalog #: 102-11679
Rabbit Anti-Human IREB2 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P48200 |
| Gene Id | 3658 |
| Gene Symbols | IREB2 |
| Protein Name / Synonyms | IREB2 (Center) |
| Clonality | Polyclonal |
| Preparation | This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2. |
| Concentration (lot specific) | 0.350 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, FC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Specificity
Predicted Reactivity
Mouse, Rat, Pig
Other Names
IREB2; Iron-responsive element-binding protein 2; Iron regulatory protein 2
NCBI Accession #
NP_004127.1
Other Accession #
Q62751; B3VKQ2; Q811J3; NP_004127.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
105045
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50; FC: 1:10-50
 | IREB2 Antibody (Center) (Cat# 102-11679) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the IREB2 antibody detected the IREB2 protein (arrow). |
 | IREB2 Antibody (Center) (Cat# 102-11679)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IREB2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | IREB2 Antibody (Center) (Cat# 102-11679) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.