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Anti-KCNQ2 Antibody
Catalog #: 144-65416
KCNQ2 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | O43526 |
| Gene Id | 3785 |
| Gene Symbols | KCNQ2 |
| Protein Name / Synonyms | KCNQ2, BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2, potassium voltage-gated channel subfamily Q member 2 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Dilutions
WB 1:500 - 1:2000
Format
Calculated MW
44kDa/92kDa/93kDa/94kDa/95kDa
Observed MW
96kDa
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 254-393 of human KCNQ2 (NP_742107.1).
Modification
Unmodified
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.