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Anti-Keratin 17 Antibody
Catalog #: 102-25599
Rabbit Anti-Keratin 17 Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | Q04695 |
| Gene Id | 3872 |
| Gene Symbols | KRT17 |
| Protein Name / Synonyms | Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17 |
| Clonality | Polyclonal |
| Recommended Applications | Western Blotting, IF, IHC |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
Other Information
Antigen Type
Synthetic Peptide
Images
WB ( 1:1000)
Western blot analysis of lysates from Hela,A431 cell line (from left to right),using Keratin 17 Antibody(C0242). C0242 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
IF (1:100)
Immunofluorescence analysis of HepG2 cells, using keratin 17 antibody. The negative controls in the ICC image is produced with the immunizing peptide.
IHC (1:50-1:100)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using keratin 17 antibody. The negative controls in the IHC image is produced with the immunizing peptide.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.