Mouse Anti-KMT3C / SMYD2 Antibody, 100 µl
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Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Mouse |
| Accession Number | Q9NRG4 |
| Gene Id | 56950 |
| Gene Symbols | SMYD2 |
| Protein Name / Synonyms | Histone methyltransferase SMYD2;HSKM B;HSKM-B;HSKMB;KMT3C;Lysine N-methyltransferase |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:1000)
Western blot detection of KMT3C / SMYD2 in 3T3,HT1080,A431 and Jurkat cell lysates and using KMT3C / SMYD2 mouse mAb (1:1000 diluted). Predicted band size: 50KDa.Observed band size: 50KDa.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.