Product Description

Specifications

Size	100 µg
Estimated Lead Time	1-2 weeks
Species	Human
Specificity	Other species not known
Host Species	Mouse
Accession Number	P01701,P0CG04
Gene Id	3535
Gene Symbols	IGLV1-51, IGLC1
Protein Name / Synonyms	Immunoglobulin lambda variable 1-51 (Ig lambda chain V-I region BL2) (Ig lambda chain V-I region EPS) (Ig lambda chain V-I region NEW) (Ig lambda chain V-I region NIG-64), Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region)
Immunogen	Purified human Ig was used as the immunogen for this Lambda light chain antibody.
Isotype	Kappa, IgG2a
Purity	Protein G affinity chromatography
Concentration (lot specific)	1 mg/ml in 1X PBS (pH 7.4), BSA free, sodium azide free
Recommended Applications	FACS: 0.5-1ug/million cells IF: 1-2ug/ml Western Blotting: 0.5-1ug/ml IHC (FFPE): 0.5-1ug/ml for 30 minutes at RT (1) Prediluted format: incubate for 30 min at RT (2)
Domain / Region / Terminus	Cell surface, cytoplasmic and secreted
Shipping Type	Blue ice
Storage	≤-20°C

Description

This antibody is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.