Anti-LIN7C (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9NUP9
Gene Id	55327
Gene Symbols	LIN7C
Protein Name / Synonyms	LIN7C (C-term)
Clonality	Polyclonal
Preparation	This LIN7C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human LIN7C.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	IHC-P, Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Specificity

Predicted Reactivity

Mouse, Rat, Bovine

Other Names

LIN7C; MALS3; VELI3; Protein lin-7 homolog C; Mammalian lin-seven protein 3; Vertebrate lin-7 homolog 3

NCBI Accession #

NP_060832.1

Other Accession #

Q792I0; O88952; Q0P5F3; NP_060832.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

21834

Recommended Dilutions

IHC: 1:10-50; WB: 1:1000

	LIN7C Antibdy (C-term) (Cat# 102-11739)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LIN7C Antibdy (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	LIN7C Antibody (C-term) (Cat# 102-11739) western blot analysis in MCF-7,NCI-H292 cell line lysates (35ug/lane).This demonstrates the LIN7C antibody detected the LIN7C protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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