Anti-LOX (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P28300
Gene Id	4015
Gene Symbols	LOX
Protein Name / Synonyms	LOX (Center)
Clonality	Monoclonal
Preparation	This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
Concentration (lot specific)	0.380 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Specificity

Predicted Reactivity

Mouse, Rat, Pig

Other Names

LOX; Protein-lysine 6-oxidase; Lysyl oxidase

NCBI Accession #

NP_002308.2

Other Accession #

P16636; P45845; P28301; NP_002308.2

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

46944

Recommended Dilutions

WB: 1:100-500

LOX Antibody (Center) (Cat# 102-10383) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the LOX antibody detected the LOX protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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