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Anti-Macrophage / Histiocytoma Marker Antibody
Catalog #: 188-10884-IHC
Mouse anti-Human Macrophage / Histiocytoma Marker Antibody [IHC only]
Product Description
Specifications
| Size | 7 mL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Rat |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Protein Name / Synonyms | Macrophage / Histiocytoma Marker |
| Immunogen | A membrane preparation from human hepatocytes was used as the immunogen for the Macrophage / Histiocytoma Marker antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only* |
| Recommended Applications | Prediluted format : incubate for 30 min at RT (2) |
| Domain / Region / Terminus | Cell surface & cytoplasmic |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
In Western blotting, it detects an antigen of 125kDa in human liver and 135kDa in tumors of histiocytic origin. Comparative study of this mAb and a standard CD68 mAb showed that their antigens are different. Its antigen in all macrophage types studied is located on the plasma membrane and within cytoplasmic structures including lysosomes. This mAb shows a restricted reactivity to cells of the monocyte/macrophage system. It specifically reacts with blood monocytes and stains resident macrophages in a wide variety of human tissues. This mAb does not stain antigen-presenting cells, e.g., Langerhans cells. Reportedly, its reactivity is restricted to histiocytes and macrophages.
Storage
Store the Macrophage / Histiocytoma Marker antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.