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Anti-MC1R (Center) Antibody
Catalog #: 102-10333
Mouse Anti-Human MC1R (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Accession Number | Q01726 |
| Gene Id | 4157 |
| Gene Symbols | MC1R |
| Protein Name / Synonyms | MC1R (Center) |
| Clonality | Monoclonal |
| Preparation | This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq].
Specificity
Other Names
MC1R; MSHR; Melanocyte-stimulating hormone receptor; Melanocortin receptor 1
NCBI Accession #
NP_002377.4
Other Accession #
NP_002377.4
Format
Type
Mouse Monoclonal Antibody (Mab)
Calculated Molecular Weight (Da)
34706
Recommended Dilutions
WB: 1:100-250
 | MC1R Antibody (Center)(Cat# 102-10333) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the MC1R antibody detected the MC1R protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.