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Anti-MECT1 / Torc1 Antibody
Catalog #: 102-26479
Mouse Anti-MECT1 / Torc1 Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Mouse |
| Accession Number | Q6UUV9 |
| Gene Id | 23373 |
| Gene Symbols | CRTC1 |
| Protein Name / Synonyms | KIAA0616;CREB regulated transcription coactivator 1;CREB-regulated transcription coactivator 1;CRTC1;CRTC1_HUMAN;FLJ14027;KIAA0616;MECT 1;Mucoepidermoid carcinoma translocated 1;Mucoepidermoid carcinoma translocated protein 1;TORC-1;TORC1;Transducer of CREB protein 1;Transducer of regulated cAMP response element binding protein |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting, ICC, IP, FC |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:1000)
Western blot detection of MECT1 / Torc1 in Hela and Jurkat lysates using MECT1 / Torc1 mouse mAb (1:1000 diluted).Predicted band size: 78KDa.Observed band size: 78KDa.
ICC (1:300)
Immunocytochemistry stain of Hela using MECT1 / Torc1 mouse mAb (1:300).
IP (1:500)
Immunoprecipitation analysis of Hela cell lysate using MECT1 / Torc1 mouse mAb.
FC (1:100)
Flow Cytometry analysis of K562 cells stained with TORC1(N-terminus) (red, 1/100 dilution), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.