Anti-MMP13 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P45452
Gene Id	4322
Gene Symbols	MMP13
Protein Name / Synonyms	MMP13 (Center)
Clonality	Polyclonal
Preparation	This MMP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human MMP13.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IF, IHC-P
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Specificity

Predicted Reactivity

Rabbit

Other Names

MMP13; Collagenase 3; Matrix metalloproteinase-13

NCBI Accession #

NP_002418.1

Other Accession #

O62806; NP_002418.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

53820

Recommended Dilutions

WB: 1:1000; IF: 1:10-50; IHC: 1:10-50

	MMP13 Antibody (Center) (Cat# 102-12111) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MMP13 antibody detected the MMP13 protein (arrow).
	Confocal immunofluorescent analysis of MMP13 Antibody (Center)(Cat# 102-12111) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
	MMP13 Antibody (Center) (Cat# 102-12111)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP13 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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