Anti-MMP8 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P22894
Gene Id	4317
Gene Symbols	MMP8
Protein Name / Synonyms	MMP8 (N-term)
Clonality	Polyclonal
Preparation	This MMP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human MMP8.
Concentration (lot specific)	0.370 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease, Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Specificity

Other Names

MMP8; CLG1; Neutrophil collagenase; Matrix metalloproteinase-8; PMNL collagenase

NCBI Accession #

NP_002415.1

Other Accession #

NP_002415.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

53412

Recommended Dilutions

WB: 1:1000

MMP8 Antibody (N-term) (Cat# 102-12121) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MMP8 antibody detected the MMP8 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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