Anti-MOBKL1B (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q7L9L4\|Q9H8S9\|Q8BPB0\|Q3T1J9\|Q921Y0\|NP_060691.2
Gene Id	55233
Gene Symbols	MOB1A
Protein Name / Synonyms	MOB kinase activator 1A, Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B, MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B
Clonality	Polyclonal
Clone	RB19209
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.

Other Information

NCBI Accession #

NP_060691.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Calculated Molecular Weight (Da)

25080

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of MOBKL1B (arrow) using rabbit polyclonal MOBKL1B Antibody (N-term) (Cat. #102-21266). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MOBKL1B gene.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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