Anti-Mouse APC (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	P25054
Gene Id	324
Gene Symbols	APC
Protein Name / Synonyms	APC (Center)
Clonality	Polyclonal
Preparation	This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease, Cancer, Wnt-beta-Catenin Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Specificity

Other Names

APC; DP2.5; Adenomatous polyposis coli protein; Deleted in polyposis 2.5

NCBI Accession #

NP_000029.2;NP_001120982.1

Other Accession #

NP_000029.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

311646

Recommended Dilutions

WB: 1:1000

APC Antibody (Center)(Cat# 102-14214) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the APC antibody detected the APC protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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