Anti-Mouse CDw199 Antibody

Product Description

Specifications

Size	0.1 mg
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rat
Protein Name / Synonyms	CDw199
Concentration (lot specific)	1.0mg/ml
Recommended Applications	Flow Cytometry
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Specificity

This product detects mouse chemokine receptor 9 (CCR9), also known as CDw199. CCR9 is a seven transmembrane protein which is a member of the beta chemokines receptor family. CCR9 is expressed in thymus and small intestine, and mediates the recruitment and development of thymocytes in response to CCL25; the only known ligand of CCR9.

CCR9 is an alternative co-receptor with CD4 for HIV infection, and has been implicated in adult T cell leukaemia. Two alternatively spliced transcript variants have been described.

This antibody blocks CCL25-induced Ca²⁺ release, attenuating inflammation in a murine model of chronic ileitis when given in early disease stages.

Storage/Stability

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.

Format

Supplied as:

Purified IgG - liquid

Formulation:

Phosphate buffered saline

Format Type:

Purified

Preparation

Immunogen:

25 amino acids from the amino terminal of murine CCR9, coupled to KLH.

Preservative:

0.09%

Sodium Azide (NaN₃)

This product

Spleen cells from immunised Lewis rat were fused with cells of the X63-Ag8.653 myeloma cell line.

Expiration:

12 months from the date of shipment when stored properly.

Featured Products