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Anti-Mouse GITR Antibody (TNFRSF18)
Catalog #: 188-10843
Rat anti-Mouse GITR Antibody (TNFRSF18)
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Specificity | Other species not tested. |
| Host Species | Rat |
| Accession Number | O35714 |
| Gene Id | 21936 |
| Gene Symbols | TNFRSF18 GITR |
| Protein Name / Synonyms | Tumor necrosis factor receptor superfamily member 18 (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357) |
| Immunogen | Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody. |
| Isotype | IgG2b, Lambda |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | Flow Cytometry: 0.5-1ug/million cells in 0.1ml in 0.1ml Immunofluorescence: 0.5-1ug/ml |
| Domain / Region / Terminus | Secreted, cell surface |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Storage
Store the GITR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.