Anti-Mouse Myb Sumoylation Site Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	P10242
Gene Id	4602
Gene Symbols	MYB
Protein Name / Synonyms	Myb Sumoylation Site
Clonality	Polyclonal
Preparation	This Myb Sumoylation Site antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from human Myb Sumoylation Site.
Concentration (lot specific)	0.320 mg/ml
Recommended Applications	IHC-P, Western Blotting
Research Area	Cardiovascular Disease, Post-Translational Modifications
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.

Specificity

Other Names

MYB; Transcriptional activator Myb; Proto-oncogene c-Myb

NCBI Accession #

NP_001123644.1;NP_001123645.1;NP_001155128.1;NP_001155129.1;NP_001155130.1;NP_001155131.1;NP_001155132.1;NP_005366.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

72341

Recommended Dilutions

IHC: 1:50-100; WB: 1:1000

	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
	Myb Antibody (Sumo) (Cat# 102-15038) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Myb antibody detected the Myb protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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