Anti-Mouse NEDD4L (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	Q96PU5\|Q8CFI0\|NP_001138436.1\|NP_001138442.1\|NP_001138439.1
Gene Id	23327
Gene Symbols	NEDD4L
Protein Name / Synonyms	E3 ubiquitin-protein ligase NEDD4-like, 632-, NEDD42, Nedd4-2, NEDD4L, KIAA0439, NEDL3
Clonality	Polyclonal
Clone	RB34399
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.

Other Information

NCBI Accession #

NP_001138436.1;NP_001138437.1;NP_001138438.1;NP_001138439.1;NP_001138440.1;NP_001138441.1;NP_001138442.1;NP_001138443.1;NP_001230889.1;NP_056092.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Calculated Molecular Weight (Da)

111932

Antigen Source

Human

Images

WB (1:1000)

NEDD4L Antibody (Center) (Cat. #102-22096) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the NEDD4L antibody detected the NEDD4L protein (arrow).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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