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Anti-MTM1 (C-term) Antibody
Catalog #: 102-16954
Rabbit Anti-MTM1 (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q13496 |
| Gene Id | 4534 |
| Gene Symbols | MTM1 |
| Protein Name / Synonyms | MTM1 (C-term) |
| Clonality | Polyclonal |
| Preparation | This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1. |
| Concentration (lot specific) | 2.0 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.
Specificity
Other Names
MTM1; CG2; Myotubularin
NCBI Accession #
NP_000243.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
69932
Recommended Dilutions
WB: 1:1000
 | The anti-MTM1 C-term Pab (Cat# 102-16954) is used in Western blot to detect MTM1 in NCI-H460 cell lysate (lane 1) and in mouse heart tissue lysate (lane 2). |
 | Western blot showing knockdown of endogenous MTM1 expression by MTM1-targeting vectors pDM134 and pDM170. Embryonic stem (ES) cells were untreated (lane 1) or transfected with control plasmid pDCont (lane 2), MTM1-targeting plasmid pDM134 (lane 3), or pDM170 (lane 4). The blot was probed with anti-MTM1 rabbit polyclonal antibodies. -Actin was used as a loading control. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.