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Anti-MUC18 Antibody CD146
Catalog #: 188-10137
Mouse anti-Human MUC18 Antibody CD146
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P43121 |
| Gene Id | 4162 |
| Gene Symbols | MCAM,MUC18 |
| Protein Name / Synonyms | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) |
| Immunogen | Recombinant human protein was used as the immunogen for this MUC18 antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G purified antibody |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | FACS: 0.5-1ug/million cells IF: 0.5-1.0ug/ml |
| Domain / Region / Terminus | Cell surface |
| Research Area | Angiogenesis |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. MUC18 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. MUC18 / CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Storage
Store the MUC18 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.