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Anti-N-Cadherin / CDH2 Antibody, Sodium Azide Free
Catalog #: 188-11154-SAF
Mouse anti-Human/Mouse/Rat N-Cadherin Antibody / CDH2 [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Mouse |
| Accession Number | P19022 |
| Gene Id | 1000 |
| Gene Symbols | CDH2,CDHN,NCAD |
| Protein Name / Synonyms | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) |
| Immunogen | A human partial recombinant protein corresponding to the CDH2/NCAD cytoplasmic domain was used as the immunogen for this N-Cadherin antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | FACS: 0.5-1ug/10^6 cells in 0.1ml IF: 1-2ug/ml Western Blotting: 0.5-1ug/ml |
| Domain / Region / Terminus | Cytoplasmic |
| Research Area | Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CDH2 and CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. NCAD/CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, the protein has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, it is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
Storage
Store the N-Cadherin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.