Anti-NDUFV1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P49821
Gene Id	4723
Gene Symbols	NDUFV1
Protein Name / Synonyms	NDUFV1(N-term)
Clonality	Polyclonal
Preparation	This NDUFV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human NDUFV1.
Concentration (lot specific)	0.300 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Specificity

Predicted Reactivity

Mouse, Bovine, Monkey

Other Names

NDUFV1; UQOR1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Complex I-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit

NCBI Accession #

NP_001159574.1;NP_009034.2

Other Accession #

Q91YT0; Q8HXQ9; P25708; NP_009034.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

50817

Recommended Dilutions

WB: 1:1000

NDUFV1 Antibody (N-term)(Cat# 102-14270) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the NDUFV1 antibody detected the NDUFV1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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