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Anti-NKX2.2 Antibody
Catalog #: 188-11086
Rabbit anti-Human NKX2.2 Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Rabbit |
| Accession Number | O95096 |
| Gene Id | 4821 |
| Gene Symbols | NKX2-2,NKX2.2,NKX2B |
| Protein Name / Synonyms | Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B) |
| Immunogen | A human partial recombinant protein was used as the immunogen for this NKX2.2 antibody. |
| Isotype | IgG |
| Purity | Protein A affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | FACS: 0.5-1ug/10e6 cells in 0.1ml IF: 1-2ug/ml IHC (FFPE): 1-2ug/ml for 30 minutes at RT |
| Domain / Region / Terminus | Nuclear |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Storage
Store the NKX2.2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.