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Anti-OAS1 Antibody
Catalog #: 144-63378
OAS1 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | P00973 |
| Gene Id | 4938 |
| Gene Symbols | OAS1 |
| Protein Name / Synonyms | OAS1, E18/E16, IFI-4, OIAS, OIASI, 2'-5'-oligoadenylate synthase 1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.
Dilutions
WB 1:500 - 1:2000
Format
Calculated MW
41kDa/43kDa/46kDa/47kDa
Observed MW
46kDa
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OAS1 (NP_002525.2).
Modification
Unmodified
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.