Anti-PABPN1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q86U42
Gene Id	8106
Gene Symbols	PABPN1
Protein Name / Synonyms	PABPN1 (C-term)
Clonality	Polyclonal
Preparation	This PABPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.

Specificity

Predicted Reactivity

Bovine

Other Names

PABPN1; PAB2; PABP2; Polyadenylate-binding protein 2; Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1

NCBI Accession #

NP_004634.1

Other Accession #

Q28165; NP_004634.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

32749

Recommended Dilutions

WB: 1:1000

PABPN1 Antibody (C-term) (Cat# 102-13158) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PABPN1 antibody detected the PABPN1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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