Anti-PARK8 (LRRK2) (L899) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q5S007\|NP_940980
Gene Id	120892
Gene Symbols	LRRK2
Protein Name / Synonyms	Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8
Clonality	Polyclonal
Clone	RB7199
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.

Other Information

NCBI Accession #

NP_940980.3

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Calculated Molecular Weight (Da)

286103

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of PARK8 (LRRK2) (arrow) using rabbit polyclonal PARK8 (LRRK2)Antibody (L899)(Cat# 102-27171). (A) 293 cell lysate (2 ug) transiently transfected with the PARK8 gene (Origene Technologies). (B) Mouse brain lysates (35ug/lane). PARK8 (arrow) was detected using the purified polyclonal antibody.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products