Anti-PCDHB3 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9Y5E6
Gene Id	56132
Gene Symbols	PCDHB3
Protein Name / Synonyms	PCDHB3 (N-term)
Clonality	Polyclonal
Preparation	This PCDHB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human PCDHB3.
Concentration (lot specific)	0.400 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Specificity

Other Names

PCDHB3; Protocadherin beta-3

NCBI Accession #

NP_061760.1

Other Accession #

NP_061760.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

86773

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	PCDHB3 Antibody (N-term) (Cat# 102-11416) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PCDHB3 antibody detected the PCDHB3 protein (arrow).
	PCDHB3 Antibody (N-term) (Cat# 102-11416)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCDHB3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of PCDHB3 Antibody (N-term)(Cat# 102-11416) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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