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Anti-Perlecan Antibody (HSPG)
Catalog #: 188-10451-IHC
Rat anti-Human/Monkey/Cow/Pig/Mouse/Fish Perlecan Antibody (HSPG) [IHC only]
Product Description
Specifications
| Size | 7 mL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Specificity | Other species not tested. |
| Host Species | Rat |
| Accession Number | P98160 |
| Gene Id | 3339 |
| Gene Symbols | HSPG2 |
| Protein Name / Synonyms | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin, LG3 peptide] |
| Immunogen | A murine EHS laminin preparation was used as the immunogen for the Perlecan antibody. |
| Isotype | Kappa, IgG2a |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only* |
| Recommended Applications | Prediluted format : incubate for 30 min at RT (2) |
| Domain / Region / Terminus | Basement membrane |
| Research Area | Angiogenesis, Inflammation |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Storage
Store the Perlecan antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.