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Anti-Phospho-CAV1-Y14 Antibody
Catalog #: 144-50761
Phospho-CAV1-Y14 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q03135 |
| Gene Id | 857 |
| Gene Symbols | CAV1 |
| Protein Name / Synonyms | CAV1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, caveolin-1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting |
| Research Area | Angiogenesis, Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Dilutions
WB 1:1000 - 1:2000
Format
Calculated MW
17kDa/20kDa
Observed MW
Immunogen
A synthetic phosphorylated peptide around Y14 of human CAV1 (NP_001744.2).
Modification
Phospho Y14
Storage
Store at -20°. Avoid freeze / thaw cycles.
Expiration:
12 months from the date of shipment when stored properly.