Anti-Phospho-CDK1 (S39) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P06493
Gene Id	983
Gene Symbols	CDK1
Protein Name / Synonyms	Phospho-CDK1(S39)
Clonality	Polyclonal
Preparation	This CDK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S39 of human CDK1.
Concentration (lot specific)	0.410 mg/ml
Recommended Applications	Dot Blotting, Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.

Specificity

Predicted Reactivity

Mouse, Rat, Bovine, Chicken

Other Names

CDK1; CDC2; CDC28A; CDKN1; P34CDC2; Cyclin-dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase

NCBI Accession #

NP_001777.1;NP_203698.1

Other Accession #

P39951; P11440; P13863; P48734

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

34095

Recommended Dilutions

DB: 1:500; WB: 1:1000; IHC: 1:50-100

	Dot blot analysis of anti-CDK11-S39 Phospho-specific Pab (Cat# 102-15287) on nitrocellulose membrane. 50ng of nonphospho-peptide or phospho-peptide were adsorbed on their respective dots. Antibody working concentration was 0.5ug per ml.
	The anti-Phospho-CDK1-S39 Pab (Cat# 102-15287) is used in Western blot for detection in Ramos tissue lysate.
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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