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Anti-Phospho-CRK-Y221 Antibody
Catalog #: 144-50789
Phospho-CRK-Y221 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | P46108 |
| Gene Id | 1398 |
| Gene Symbols | CRK |
| Protein Name / Synonyms | CRK, CRKII, p38, adapter molecule crk |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Dilutions
WB 1:500 - 1:2000
Format
Calculated MW
22kDa/33kDa
Observed MW
38kDa
Immunogen
A synthetic phosphorylated peptide around Y221 of human CRK (NP_058431.2).
Modification
Phospho Y221
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.