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Anti-Phospho-EIF4EBP1-S65 Antibody
Catalog #: 144-50629
Phospho-EIF4EBP1-S65 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q13541 |
| Gene Id | 1978 |
| Gene Symbols | EIF4EBP1 |
| Protein Name / Synonyms | EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E-binding protein 1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IP |
| Research Area | mTOR Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Dilutions
WB 1:500 - 1:2000; IP 1:50 - 1:100
Format
Calculated MW
12kDa
Observed MW
18kDa
Immunogen
A synthetic phosphorylated peptide around S65 of human EIF4EBP1 (NP_004086.1).
Modification
Phospho S65
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.