Anti-Phospho-Estrogen Receptor alpha-S118 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P03372
Gene Id	2099
Gene Symbols	ESR1
Protein Name / Synonyms	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Recommended Applications	Western Blotting, IHC, IF
Research Area	Inflammation, Endocrine
Shipping Type	Blue ice
Storage	-20°C

Description

Background

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Dilutions

WB 1:500 - 1:2000; IHC 1:50 - 1:100; IF 1:100 - 1:200

Format

Calculated MW

35kDa/47kDa/53kDa/66kDa

Observed MW

66kDa

Immunogen

A phospho specific peptide corresponding to residues surrounding S118 of human Estrogen Receptor alpha

Modification

Phospho S118

Storage

Store at -20°. Avoid freeze / thaw cycles.

Images

Western blot

Expiration:

12 months from the date of shipment when stored properly.

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