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Anti-Phospho-Lck-Y505 Antibody
Catalog #: 144-50678
Phospho-Lck-Y505 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P06239 |
| Gene Id | 3932 |
| Gene Symbols | LCK |
| Protein Name / Synonyms | LCK, IMD22, LSK, YT16, p56lck, pp58lck, tyrosine-protein kinase Lck |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IP |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
Dilutions
WB 1:500 - 1:2000; IP 1:50 - 1:100
Format
Calculated MW
40kDa/58kDa/61kDa
Observed MW
Immunogen
A synthetic phosphorylated peptide around Y505 of human Lck (NP_001036236.1).
Modification
Phospho Y505
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.