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Anti-Phospho-MET-Y1234/1235 Antibody
Catalog #: 144-50726
Phospho-MET-Y1234/1235 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P08581 |
| Gene Id | 4233 |
| Gene Symbols | MET |
| Protein Name / Synonyms | MET, AUTS9, DFNB97, HGFR, RCCP2, c-Met, hepatocyte growth factor receptor |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting |
| Research Area | Cancer, Autophagy |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
Dilutions
WB 1:500 - 1:2000
Format
Calculated MW
85kDa/155kDa/157kDa
Observed MW
156kDa
Immunogen
A synthetic phosphorylated peptide around Y1234 & Y1235 of human MET (NP_000236.2).
Modification
Phospho Y1234/1235
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.