Anti-Phospho-p38 MAPK-T180/Y182 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q16539
Gene Id	1432
Gene Symbols	MAPK14
Protein Name / Synonyms	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, mitogen-activated protein kinase 14
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Recommended Applications	Western Blotting, IF
Research Area	Angiogenesis, Cancer, Inflammation, MAPK Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Dilutions

WB 1:500 - 1:2000; IF 1:50 - 1:200

Format

Calculated MW

29kDa/34kDa/35kDa/41kDa

Observed MW

41kDa

Immunogen

A synthetic phosphorylated peptide around T180 & Y182 of human p38 MAPK (NP_620581.1).

Modification

Phospho T180/Y182

Storage

Store at -20°. Avoid freeze / thaw cycles.

Images

Western blot

Expiration:

12 months from the date of shipment when stored properly.

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